All Questions
Tagged with opioid pharmacology
5 questions
6
votes
2
answers
371
views
What structural features make a molecule a potent opioid receptor agonist?
For instance, take morphine. It is used as a baseline for measuring the potency of opioid agonists. Its structure looks like this:
But then, take heroin, around three times as potent, its structure ...
- 527
2
votes
2
answers
352
views
What Role Antagonists Play in the Study of Drugs?
I am pretty unfamiliar to pharmacology. I'm doing a research on drug abuse, particularly opioids' mechanism of action. I encountered several times evidences that come from studies using antagonists ...
- 315
3
votes
1
answer
129
views
Which enzymes degrade dynorphins and what drugs inhibit these enzymes?
Which enzymes degrade dynorphins and what drugs are there available to inhibit said enzymes?
- 2,398
3
votes
1
answer
347
views
What's the therapeutic index of Pethidine (Meperidine in the US)?
What's the therapeutic index $\left(\frac{LD_{50}}{ED_{50}}\right)$ of Pethidine (Meperidine in the US) via the intravenous route for humans or whatever species you can find? The therapeutic window $\...
- 2,398
1
vote
0
answers
1k
views
How do Opioids Stimulate a Histamine Release?
Histamine is a neurotransmitter that also has peripheral functions such as the regulation of gastric acid secretions, allergic responses, etc. I know that opioids stimulate a release of histamine but ...
- 2,398