Questions tagged [opioid]

Drugs that bind to the opioid receptors (mu, delta & kappa).

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How do painkillers prevent shock?

I was reading about the Placebo effect and came across this little story: The roots of the placebo problem can be traced to a lie told by an Army nurse during World War II as Allied forces ...
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1answer
72 views

Narcan nasal spray

A recent podcast of Radiolab (time index 3:05) described a person who had overdosed given the nasal spray form of Narcan. The report indicated the patient was awake seconds after the spray was ...
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223 views

What structural features make a molecule a potent opioid receptor agonist?

For instance, take morphine. It is used as a baseline for measuring the potency of opioid agonists. Its structure looks like this: But then, take heroin, around three times as potent, its structure ...
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Is lowered blood pressure a primary lethal symptom of an opiate overdose?

When someone has a opiate overdose, they can have no or almost no pulse and can have shallow breathing or stop breathing. When you stop breathing (for example) by drowning, you can survive for a long ...
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1answer
4k views

What is 'calcium conductance'?

What is the meaning of calcium conductance in ion channels. I encountered this in the following text: It was established that the µ and δ opioid receptors open potassium channels, which results ...
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2answers
285 views

What Role Antagonists Play in the Study of Drugs?

I am pretty unfamiliar to pharmacology. I'm doing a research on drug abuse, particularly opioids' mechanism of action. I encountered several times evidences that come from studies using antagonists ...
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1answer
104 views

Which enzymes degrade dynorphins and what drugs inhibit these enzymes?

Which enzymes degrade dynorphins and what drugs are there available to inhibit said enzymes?
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1answer
328 views

What's the therapeutic index of Pethidine (Meperidine in the US)?

What's the therapeutic index $\left(\frac{LD_{50}}{ED_{50}}\right)$ of Pethidine (Meperidine in the US) via the intravenous route for humans or whatever species you can find? The therapeutic window $\...
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1k views

How do Opioids Stimulate a Histamine Release?

Histamine is a neurotransmitter that also has peripheral functions such as the regulation of gastric acid secretions, allergic responses, etc. I know that opioids stimulate a release of histamine but ...