Questions tagged [opioid]
Drugs that bind to the opioid receptors (mu, delta & kappa).
9 questions
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How do painkillers prevent shock?
I was reading about the Placebo effect and came across this little story:
The roots of the placebo problem can be traced to a lie told by an
Army nurse during World War II as Allied forces ...
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Narcan nasal spray
A recent podcast of Radiolab (time index 3:05) described a person who had overdosed given the nasal spray form of Narcan. The report indicated the patient was awake seconds after the spray was ...
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What structural features make a molecule a potent opioid receptor agonist?
For instance, take morphine. It is used as a baseline for measuring the potency of opioid agonists. Its structure looks like this:
But then, take heroin, around three times as potent, its structure ...
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Is lowered blood pressure a primary lethal symptom of an opiate overdose?
When someone has a opiate overdose, they can have no or almost no pulse and can have shallow breathing or stop breathing. When you stop breathing (for example) by drowning, you can survive for a long ...
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What is 'calcium conductance'?
What is the meaning of calcium conductance in ion channels. I encountered this in the following text:
It was established that the µ and δ opioid receptors open potassium
channels, which results ...
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What Role Antagonists Play in the Study of Drugs?
I am pretty unfamiliar to pharmacology. I'm doing a research on drug abuse, particularly opioids' mechanism of action. I encountered several times evidences that come from studies using antagonists ...
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Which enzymes degrade dynorphins and what drugs inhibit these enzymes?
Which enzymes degrade dynorphins and what drugs are there available to inhibit said enzymes?
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What's the therapeutic index of Pethidine (Meperidine in the US)?
What's the therapeutic index $\left(\frac{LD_{50}}{ED_{50}}\right)$ of Pethidine (Meperidine in the US) via the intravenous route for humans or whatever species you can find? The therapeutic window $\...
- 2,398
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How do Opioids Stimulate a Histamine Release?
Histamine is a neurotransmitter that also has peripheral functions such as the regulation of gastric acid secretions, allergic responses, etc. I know that opioids stimulate a release of histamine but ...
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