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Questions tagged [opioid]

Drugs that bind to the opioid receptors (mu, delta & kappa).

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73 views

Is lowered blood pressure a primary lethal symptom of an opiate overdose?

When someone has a opiate overdose, they can have no or almost no pulse and can have shallow breathing or stop breathing. When you stop breathing (for example) by drowning, you can survive for a long ...
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1answer
4k views

What is 'calcium conductance'?

What is the meaning of calcium conductance in ion channels. I encountered this in the following text: It was established that the µ and δ opioid receptors open potassium channels, which results ...
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2answers
214 views

What Role Antagonists Play in the Study of Drugs?

I am pretty unfamiliar to pharmacology. I'm doing a research on drug abuse, particularly opioids' mechanism of action. I encountered several times evidences that come from studies using antagonists ...
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1answer
268 views

Can Opioids Attenuate some of the symptoms of Psychosis?

Can Opioids Attenuate some of the symptoms of Psychosis? I ask because there's a dead link on the Wikipedia page that's meant to support the notion that opioids attenuate some of the symptoms of ...
3
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1answer
100 views

Which enzymes degrade dynorphins and what drugs inhibit these enzymes?

Which enzymes degrade dynorphins and what drugs are there available to inhibit said enzymes?
3
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1answer
323 views

What's the therapeutic index of Pethidine (Meperidine in the US)?

What's the therapeutic index $\left(\frac{LD_{50}}{ED_{50}}\right)$ of Pethidine (Meperidine in the US) via the intravenous route for humans or whatever species you can find? The therapeutic window $\...
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0answers
1k views

How do Opioids Stimulate a Histamine Release?

Histamine is a neurotransmitter that also has peripheral functions such as the regulation of gastric acid secretions, allergic responses, etc. I know that opioids stimulate a release of histamine but ...