Stack Exchange Network

Stack Exchange network consists of 175 Q&A communities including Stack Overflow, the largest, most trusted online community for developers to learn, share their knowledge, and build their careers.

Visit Stack Exchange

Questions tagged [opioid]

Drugs that bind to the opioid receptors (mu, delta & kappa).

1
vote
0answers
27 views

How do painkillers prevent shock?

I was reading about the Placebo effect and came across this little story: The roots of the placebo problem can be traced to a lie told by an Army nurse during World War II as Allied forces ...
2
votes
1answer
53 views

Narcan nasal spray

A recent podcast of Radiolab (time index 3:05) described a person who had overdosed given the nasal spray form of Narcan. The report indicated the patient was awake seconds after the spray was ...
5
votes
2answers
154 views

What structural features make a molecule a potent opioid receptor agonist?

For instance, take morphine. It is used as a baseline for measuring the potency of opioid agonists. Its structure looks like this: But then, take heroin, around three times as potent, its structure ...
1
vote
0answers
74 views

Is lowered blood pressure a primary lethal symptom of an opiate overdose?

When someone has a opiate overdose, they can have no or almost no pulse and can have shallow breathing or stop breathing. When you stop breathing (for example) by drowning, you can survive for a long ...
2
votes
1answer
4k views

What is 'calcium conductance'?

What is the meaning of calcium conductance in ion channels. I encountered this in the following text: It was established that the µ and δ opioid receptors open potassium channels, which results ...
2
votes
2answers
238 views

What Role Antagonists Play in the Study of Drugs?

I am pretty unfamiliar to pharmacology. I'm doing a research on drug abuse, particularly opioids' mechanism of action. I encountered several times evidences that come from studies using antagonists ...
2
votes
1answer
313 views

Can Opioids Attenuate some of the symptoms of Psychosis?

Can Opioids Attenuate some of the symptoms of Psychosis? I ask because there's a dead link on the Wikipedia page that's meant to support the notion that opioids attenuate some of the symptoms of ...
3
votes
1answer
101 views

Which enzymes degrade dynorphins and what drugs inhibit these enzymes?

Which enzymes degrade dynorphins and what drugs are there available to inhibit said enzymes?
3
votes
1answer
327 views

What's the therapeutic index of Pethidine (Meperidine in the US)?

What's the therapeutic index $\left(\frac{LD_{50}}{ED_{50}}\right)$ of Pethidine (Meperidine in the US) via the intravenous route for humans or whatever species you can find? The therapeutic window $\...
1
vote
0answers
1k views

How do Opioids Stimulate a Histamine Release?

Histamine is a neurotransmitter that also has peripheral functions such as the regulation of gastric acid secretions, allergic responses, etc. I know that opioids stimulate a release of histamine but ...