14
votes
Accepted
Meaning of "acute LSD"
In the abstract they refer to "acute LSD administration" (emphasis mine), and in the next section of the results after the one you mention in your question, they clarify it as "Acute ...
- 15.3k
6
votes
Accepted
What is two photon calcium imaging?
what does the "two photon" means?
Ordinary confocal microscopy uses single photon of laser light to excite the molecule of fluorescent dye.
In two photon microscopy you use two photons, with lower ...
- 736
5
votes
Accepted
Why do classic psychedelics not cause withdrawal, despite high tolerance?
Short answer
Withdrawal effects are generally associated with drugs that induce feelings of euphoria by stimulating the reward center of the brain, either directly (cocaine, morphine) or indirectly (...
- 52.6k
5
votes
Why is Cacao a stimulant?
Cacao and products made from cacao contain a number of bioactive compounds. As far as the subjective sensation of a "buzz", there are three related alkaloids present in cacao that may account for this ...
- 8,831
4
votes
Accepted
How to make GABA pass the blood brain barrier?
Short answer
Chemical reversible shielding of the aminogroup in GABA seems to be sufficient to get it into the brain as a Trojan horse.
Background
Given that you ask
...how to make GABA pass ...
- 52.6k
3
votes
Why is atropine a CNS stimulant, although it blocks the muscarinic receptors in the brain?
Short answer
Atropine inhibits an inhibitor and hence its effects are excitatory.
Background
According to the wiki page on muscarine M2 receptor:
M2 muscarinic receptors act via a Gi type ...
- 52.6k
3
votes
Why does excess dopamine activity in the pleasure centers results in less pleasure in schizophrenics?
Short answer
The dopamine hypothesis includes brain regions with reduced dopamine transmission as well. The prefrontal cortex in specific has reduced dopaminergic activity and is implicated in ...
- 52.6k
2
votes
Differences in the action of Scopolamine and Atropine
It seems that the reason for the different effect of Atropine and Scopolamine on the brain is related to the structural difference between them.
From the chemical structures below it is evident that ...
- 484
1
vote
How fast is dopamine released in the brain?
Dopamine is a neurotransmitter and released from synaptic ends via transporters. Such a release happens within milliseconds; the time present Dopamin needs to move some tens of nanometers.
Adrenalin ...
- 1,597
1
vote
Why is Cacao a stimulant?
There are probably over a hundred compounds in cacao that might possibly have effects on humans. I don't want to speculate on the ones that are not known. One that is known is theobromine.
I have ...
- 181
1
vote
Accepted
How is ATP converted to adenosine?
For a full understanding I refer you to the KEGG pathway map which is fairly comprehensive in showing all the metabolic processes that CAN produce Adenosine.
It's a bit daunting but if you find it on ...
1
vote
Accepted
Consistency of consciouness
You trespass upon a question as old as antiquity: what properties constitute consciousness? The best means to respond to the question concerns a metaphysical answer and an answer in modern biology
We ...
- 439
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