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Questions tagged [genetic-linkage]

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How to identify whether something is in linkage disequilibrium?

If the following loci indicated the presence of an SNP in flu strains, is Locus 2 and Locus 3, which are located 10 bp apart in linkage disequilibrium? "When alleles and molecular markers are ...
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1answer
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Linkage between chromosomal loci and the Hardy-Weinberg principle

Referring to the Hardy-Weinberg principle, which is always stated with respect to a particular locus on the chromosome, if we observe that two different loci are either always together in Hardy-...
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Non-coding DNA correlation with rate of evolution

Non-coding DNA can be helpful in generating useful mutations that can go on to become new features/functionality of an organism. Non-coding DNA also indirectly reduces chances of mutation of useful/...
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What exactly is a centimorgan? [duplicate]

Centimorgan's aren't physical distances. The analogy that I could come up with is if you had an array with 10 items, A = [a, b, c, d, e, f ,g ,h ,i ,j, k] The ...
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1answer
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Linkage Disequilibrium - What does it mean when D < 0?

What does it mean when you have a situation where your D<0?
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1answer
264 views

Sex linked genes?

I am learning about genetics and sex-linked traits. All of the X-linked traits we have considered (eye colour in Drosophila, Duchene Muscular Dystrophy to name a couple)follow the rule that, a female ...
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Calculating gene separation -a genetics problem

I am really struggling with genetics. In particular, I have the following question Now I am OK with calculating the separation of genes in centrimorgans when I have data like so: But in the first ...
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1answer
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What is the exact concept of “Repulsion” and “Coupling” (Genetics)?

From all sorts of books including standard books (like those by Tamarin, Griffith etc) as well as internet; I could not clear-up many things about "Repulsion" and "Coupling". Such as:- Is "Coupling" ...
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Is complete linkage found in all four chromosomes or only Y-chromosome of Drosophila? [duplicate]

Male Drosophila shows complete linkage. Is it observed for all four chromosomes or only the Y chromosome?
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Is complete genetic linkage possible?

Linkage is the tendency of genes on the same chromosome to remain together during the process of inheritance. Is it possible that two genes will remain linked generation after generation without any ...
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1answer
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What test to apply to detect genomic signatures of selection?

I would like to ask you for your sugestions for selecting a test to detect signatures of selection in the following mouse model: We have three groups: animals exhibiting trait A, trait B and controls....
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2answers
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Genetic linkage greater than 50 centimorgans

Classically, the linkage between two loci can be measured in centimorgans (cM), which represents the percent chance that these two loci will recombine an odd number of times (generating a recombinant ...
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Cut-off values for LD, LOD and D-prime as algorithmic input

I created an algorithm to generate SNPs for random people of different descents - based on HapMap data. While this works good, there is something else I want to take into consideration. So if a SNP ...
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1answer
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Mitochondrial D-Loop

I know that the D-loop is a DNA complex in which the strands of double helix DNA molecule are separated for a stretch and held apart by a third strand of DNA. Usually, this third strand has a base ...
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1answer
543 views

Why does allele linkage cause disproportionate phenotypic ratios? [closed]

I was learning about allele linkage in Biology class and I got confused by the resultant phenotypic ratios. Say you have a dihybrid cross BbGg x BbGg. The Punnett square would look like the ...
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1answer
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How to decide if genes are linked in an unordered mapping problem?

From what I understand, if the tetrads resulting from a cross exhibit the same number of parental ditypes as there are nonparental ditypes, then the genes under consideration are said to be unlinked. ...
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0answers
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Linkage disequilibrium D sign

Linkage disequilibrium D equals $D=x_{11}−p1⋅q1$ where: Haplotype Frequency $A_{1}B_{1} = x_{11}$ $A_{1}B_{2} = x_{12}$ $A_{2}B_{1} = x_{21}$ $A_{2}B_{2} ...
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A Genetic linkage problem [closed]

I have recently switched from electronics to computational biology. So having some hard time with my homeworks. Can someone guide me on this problem? Consider 6 genes A, B, C, D, E, F, G. Some ...
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Possible Genotypes — Linked Genes

Please consider the following question: Genes A and B are located on the same chromosome. If two individuals with the genotype shown below are crossed, which genotype could be formed? Let / ...
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1answer
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What is the genetic distance where linkage can be ignored?

I heard several times that two SNPs, that have at least 1'000 nucleotides between them, can be seen as 'unlinked' due to frequent recombination events. I also once saw a paper showing a graph "degree ...
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1answer
4k views

recombination frequency problem

Three loci C, D and E are located on the same chromosome in this order. We found that the frequency of recombinants between C and D is 10% and that between D and E it is 20%. Assuming that ...
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1answer
435 views

Linkage distance calculation

What is the map unit distance between L and S allele ? My working : If we take the normal ratio :9:3:3:1 , first one should be 9/16 = 0.5625 and then subtract 0.51 from it, we get 0.0525, similarly ...