All Questions
Tagged with inheritance or genetics
2,516 questions
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How can the most genetically similar populations to Ashkenazi Jews from an admixture standpoint be Italians, Greeks, Turks, and Armenians?
In this study from 2016, Ashkenazi Jews are shown to be the most similar from an admixture analysis test to populations not traditionally associated with being geographically near Ashkenazi Jews. This ...
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can anyone help me with this question?
During exercise, a capillary of radius 𝑅=500𝜇m
and length 𝐿=0.1cm.
L=0.1 cm supplies oxygen to surrounding muscle tissue. Blood flows through the capillary with a volumetric flow rate 𝑄=1𝜇L/s. ...
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How to determine a gene based on the biological function of an organism?
I am studying genetic engineering.
I have a problem understanding how to find the necessary genes responsible for certain phenotypic traits.
Let's say plants have red petals. What methods are used to ...
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Why does monoculture cause lower microbiome diversity and health in bees and how can we fix it? [closed]
How can you be sure certain microbes only grow on limited plants, so bees can only swallow limited microbes in a monoculture environment? Why can't bees just evolve to eat or lick dirtier places such ...
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What particular genetic mutations gave Europeans increased resistance to smallpox?
It's widely stated that a large chunk of the Native American population was wiped out by diseases (Notably smallpox) introduced by European colonists to which the natives did not have a resistance. My ...
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Does this evolutionary model of mutations have a flaw?
In a youtube video by an evolutionary biologist titled Creation Myths: Genetic Entropy at 14:50 he explains that the ratio between beneficial + neutral mutations and deleterious mutations decreases ...
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Quantitatively measure the impact of DNA vs epigenetics?
Background: While classical genetics deals with how DNA sequences directly code for traits, epigenetics involves chemical modifications to DNA and associated proteins that can switch genes on or off ...
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Genomics vendors with publicly available pricing
Are there vendors for genomics with publicly available pricing?
Motivation:
I'm curious why the reagents needed for gene cloning using bacterial plasmid costs 100-150 USD, and why this can't be made ...
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2
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Why isn't all genetics work published on GitHub?
Update: When hackernews is ruthlessly critical of a new software project, the implicit assumption is that software projects are dime-at-dozen, attention of HN users is worth millions of dollars, hence ...
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If both parent squash are edible can the child squash be toxic?
Assuming contamination from a toxic squash didn't occur, could cross pollination of two edible squashes be toxic?
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How to test whether correlation of couples phenotypes is due to assortative mating or environment?
A few phenotypes are easier to pinpoint as assortative mating (height for example), But other phenotypes such as vitamin D, weight, etc could be a combination of shared environment and assortative ...
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Understanding STR to SNP imputation methods
I am struggling to find the exact step-by-step algorithm of STR to SNP imputation, but failing so far. I figured there's Beagle software, but I can't find out how it works (math behind it). My actual ...
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Sanger Method - DNA sequencing
I'm having a little bit of trouble understanding the Sanger method of DNA sequencing. How can you determine the order of the sequence just by the length of the fragment the ddNTP is attached to?
For ...
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Crossover Equivalence - Does AB/ab X AB/ab result in no effect in crossover 50% of the time when crossover occurs?
I might be using symbols wrong, so my symbol definitions for this post:
DEFINITIONS:
AB / ab : gene alignment on chromatids.
Another way of looking at the above is
...
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Why do bacteria need the CRISPR system?
I'm learning about CRISPR at my college. I understand that when viral DNA is inserted into a bacterial cell, the Cas1-Cas2 proteins identify the PAM site in the viral DNA and then cut the protospacer ...
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Does the hard shell of a chicken egg come from the genetics of the chick or of the mother?
Brought to you by my "what came first, the chicken or the egg?" debate with my elementary aged children.
What causes a chicken egg to develop a hard shell? Does the zygote/embryo create this ...
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Hardy Weinberg Equilibrium; Homozygous individuals
I have the following exercise that I can't solve:
In a sample there are 16 homozygous A1 allele carriers
(A1/A1) and 24 heterozygous A1/A2 allele carriers. How many homozygous A2 allele carriers (A2/...
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(NSAA 2023 Section 1 Q80) Does a haploid blood cell exist?
I recently worked through the NSAA 2023 paper (the admissions test for those who wish to study Natural Sciences at the University of Cambridge) with my students and encountered the following question:
...
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Lyonization in individuals with Turner syndrome
As people with Turner's syndrome have XO chromosomes, does the lyonization of the single X chromosome take place in the somatic cells? Is this one of the reasons for the abnormalities associated with ...
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Are these cassettes suitable for expressing PETase mutant in E. coli?
I created two potential gene expression cassettes (constitutive and inducible) for expression of a mutant PETase gene on PeptiCloud using the version tree feature, which allows users to create ...
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Book on data science talking about both DNA and RNA
I do not have any eductatin in biology, I am a mathematician. However I am reading a book in data science, and am trying to understad an example involving, DNA, mRNA and genes.
From what I understand ...
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Post-Translational Modification in insulin production
When searching "How is insulin produced commercially" on Google, most results simply say something along the lines of "The insulin gene is inserted into a bacteria, which then express ...
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What backbone to use for Helper dependent adenovirus (HDAd)
I have been trying to design a plasmid for a helper dependent adenovirus but while looking i wasn't able to see a backbone specifically for HDAds so I was wondering if a general adenovirus backbone ...
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How to model the relationship between environments based on environmental covariates in a genomic prediction context
I have a dataset with different wheat lines in multiple environments. For each line various traits are measured (e.g. grain yield). I am trying to set up various genomic prediction models (linear ...
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Is it possible to improve metabolic rate through quorum sensing?
I am building a microbial fuel cell unit using mint plant and soil microbes. My goal is to power a LED light using the electricity but the electrify that microbes are so little so I am thinking of ...
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How to understand restriction mapping a quarter of a century later?
Today, biology is virtually all based on massively parallel sequencing, long-strand sequencing, and metagenomic; looking back at old restriction mapping is not straightforward (at least for me).
For ...
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Mechanism of random assortment of chromosomes
How does the random assortment of chromosomes during meiosis occur?
I am a mathematician, not a biologist, and I am surprised that it is difficult to find an answer to this question online (AI ...
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About tomatoes pigments, why red tomatoes rather than yellow ones
How the first tomatoes (yellow) that arrived in Europe turned from yellow to red ?
I know the yellow pigment is xantophylle and the red one is lycopene, but my question is, was it an adaptation of the ...
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What has caused my oxeye daisies to mutate?
Some oxeye daisies (Leucanthemum vulgare) in my garden are showing strange mutations. I have a few oxeye daisy plants around my garden in different areas, but only one plant's flowers are showing ...
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4
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154
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Can phenotype change without change in genotype?
If a person with lighter skin is to live in areas close to the equator for a long amount of time, their skin would get darker, and hence their phenotype gets 'altered'.
If I'm to look at their gene ...
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What is a reference strain in DNA-DNA hybridization DNA groups?
Results
DNA groups identified:
All intra-group relatedness values are shown in
Table I.
By means of reference strains, most of the DNA groups could be identified as groups described by Bouvet & ...
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2
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How would you find out which gene is causing a specific phenotype in Drosophila through crosses only?
I'd recently attended an interview and was asked a question I've been trying to get to the bottom of. The question was that there is a mutation in which some smaller drosophila are only attracted to ...
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1
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35
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identification of most Active gene/protein isoform
I am investigating a gene, and on ensemble, it has multiple variants. How can i know which gene or protein isoform is most active?
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Limma - Voom function for microarray data
I am wondering if anyone can have a look at the voom plot I got below and let me know if this is indicative of an issue with my design?
I understand that it should be more of a J-shape rather than a ...
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Are there any completely, or 'true', Mendelian traits that do not display any polygeny at all?
Recently, I learned about polygenic traits and it got me wondering, are there any truly Mendelian traits where the trait displayed exists in a total binary?
I have looked at some questions on the ...
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107
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How to separate two plasmids from E coli with the same backbone?
I'm using transformation-associated recombination (TAR) in yeast to capture a biosynthetic gene cluster (32 kb) by transforming gDNA and a capture vector (11 kb) with homology arms. I identified a ...
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Knock-Out (KO) Mice
We have generated an induced KO mice line for a specific gene. However when i perform IF staining I can still see substantial levels of the protein for this specific gene produced, even though the ...
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How are genetic hallmarks of aging somehow “reset” at conception?
I’m a layman and genuinely curious about this, so forgive me if I use the wrong terminology or obviously don’t know what I’m talking about. Regardless of whether parents have a child at 18 or at 40, ...
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Probability of an $AABbCC$ offspring given the cross $AaBbCc\times AaBbCc$, is my solution correct?
So I have been working through the drills in the 26th edition of AP Biology Prep by The Princeton Review for fun when I came across this question in the Chapter 12 drill that I'm not really sure about ...
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What does it mean when observed genotype frequency is different from expected genotype frequency in Hardy-Weinberg equilibrium?
As I understand it, if a population is at Hardy-Weinberg equilibrium, then the genotype frequencies should be $$p^2 + 2pq + q^2 = 1,$$ given the allele frequencies of $p$ and $q$, which you can figure ...
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In the context of GWAS we have an alternate allele and a reference allele. Why do we only have one possible alternate instead of three?
I recently started analyzing a GWAS summary dataset. It has a column for the reference allele in which it mentions the base in the reference genome.
There is another column for the alternate allele (...
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3
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105
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If you want to understand evolution from a genetics standpoint what are some must reads be it books or textbooks? [closed]
The question basically sums it up. I'm looking for books/textbooks that explain evolution from a genetic perspective.
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Interpretation of narrow-sense heritability over one (using R/S = h^2)
Here is my data:
Mean height score of the total parental population: 5.2
Mean height score of selected parents (those chosen for breeding due to their higher height): 6.4
Mean height score of the ...
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What is important in the Luria-Latarjet effect?
In the seminal paper
Luria, S.E. and Latarjet, R. (1964) “Ultraviolet irradiation of
bacteriophage during intracellular growth”. Proceedings of the
National Academy of Sciences of the United States ...
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Evolution of the human Y chromosome
This recent news article suggests the number of genes in human male Y chromosome has steadily been reducing in the Y chromosome for a long time and is in danger of dying out all together.
What I want ...
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Is there a program that demonstrates overall fitness will increase in a population overtime?
Of course this will not always be the case with environmental factors, but generally speaking. I'm searching for a program that shows evolution works from a statistical standpoint.
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What is the word for a small (under 50 bp) structural variant?
What is the word for a small (under 50 bp) SV? Perhaps it is MNV (multi-nucleotide variant)? Something like microindel? I do not like SNV as "single nucleotide" is not really correct and I ...
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371
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Pedigree Analysis
I was doing some pedigree work and couldn't figure out why my answer is wrong. This chart is supposed to be an autosomal Dominant method of inheritance, but I am finding an autosomal recessive pattern ...
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109
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Why do we choose to use agar instead of agarose in various microbial applications?
When performing gel-electrophoresis we always use agarose. Is there a reason we can't perform it using Agar?
And in microbial culture Agar is commonly used as solidifying agent, could this be replaced ...
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Preserving a sample for mtDNA and nuclear DNA analysis
Imagine a person in the early half of the 20th century (1900 to 1950) took some kind of sample(s) from a living human body using any technology of the era. They then stored it using any technology ...
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