Questions tagged [stem-cells]

Cells which have not fully differentiated yet, i.e. with the potential to develop into other kinds of cells through asymmetric cell division.

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What cells in mosses behave analogously to mammalian embryonic stem cells?

The Washington Post article Ancient life awakens amid thawing ice caps and permafrost describes the work of Peter Convey, an ecologist with the British Antarctic Survey and his team, and includes a ...
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A theoretical ethical dilemma [closed]

For all those who keep in touch with advancements in field of biology iPSCs ought not to be a foreign term. iPSCs are now being used to make organ models to be able to study diseases and how drugs ...
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Is there natural occurrence of induced pluripotency / expression of Yamanaka factors and what is the evolutionary explanation of that?

Is there natural biological processes in which the full (full reprogramming into pluripotent state) or partial (partial reprogramming, stopped before point-of-no-return, preserving the functional ...
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A cure for radiation exposure?

Some of the greatest inventions of my lifetime have been from looking at nature and copying. I found out tadigrades in outer space have the ability to repair their own DNA when exposed to radiation ...
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Dental follicle cells

Are dental follicle progenitor cells and dental follicle precursor cells the same cells or they are two different cell types? Thank you.
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Why do stem cells injected into muscle become muscle cells?

In this article published in Science Daily, researchers injected teratoma-derived stem cells into mice with muscular dystrophy, and the stem cells regenerated 80% of the lost muscle. But what is the ...
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Lobed Nuclei still count as One nucleus?

Do the Lobed Nuclei of immune cells (such as Megakaryocytes) still count as one nucleus?
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Stem cells therapy for stroke via thecal sac?

According to this video posted below, stem cells for stroke patients can be induced to thecal sack, below the spinal cord. Those stem cells would make their way up to the brain. https://youtu.be/...
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Apart from nerve cells and muscle cells, what types of cells do not undergo mitosis in adult man?

Neurons and muscle cells in adult humans do not have the ability to divide by mitosis, so they can not repair themselves and their cell cycle remains in the interphase. I’m looking for more cells with ...
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Totipotent stem cells

I came across this question in my book: In terms of types of stem cells, define "totipotent". a. Cell type able to give rise to all cell types including extraembryonic cell lineages b. Cell type ...
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Are $DCX^{-}PSA-NCAM^{+}$ neurons the result of adult neurogenesis in human being?

A recent study by Sorrells et al. (2018) has stirred a debate whether human being really do have adult neurogenesis in hippocampus or not. In a following paper- Adult hippocampal neurogenesis: a ...
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How do adult differentiated somatic cells divide?

My textbook (which is Biotechnology by David P. Clark) states, when talking about fate-mapping potential stem-cells: "If the marked cell is not a stem cell, the marker will not be passed onto ...
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Are androgenic-anabolic steroids a form of gene editing?

Is taking AAS a form of gene-editing? Steroids alter genes in some way since they allow people to build more muscle than what's naturally possible -- so they sort of "break" natural genetics somehow. ...
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Self Grown Organs

Could a viable organ be partially grown in a test tube then be hooked up to the host in some way until it is large enough to swap it with the bad organ? For example: Could a smaller replacement heart ...
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Is that true that plant stem cells can be used in humans?

I was reading an article (which seems very fake to me) on sensitive topics, but there was one astonishing statement: Stem cells are obtained from certain plants that grow all over the world. Once ...
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What is the relationship between induction of cell differentiation and DNA methylation status?

This may sound like a broad question to ask, but I am working on interpreting a review article for my epigenetics course and I'm having trouble reconciling two seemingly contradictory things this ...
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What determines the physical location of differentiated cells in an organism?

Exposition: As a little kid, I always thought of DNA as being a description of how to build an organism. For example a human DNA would have "Add two legs and two arms", a dogs DNA would have ...
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What are the principles of stem cell engineering?

Suppose you want to convert the skin cell into a pluripotent stem cell. I know there are a few genes that were identified for this purpose (a recent Nobel Prize). But apart from finding such genes, it ...
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How does the Lgr5 receptor contribute to maintaining stemness in the intestine?

I don't understand the connection between Lgr5 receptor and Wnt between Paneth cells and stem cells. And how does this link to the EphB-EprinB inhibition between transit amplifying cells and ...
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Evolution of leukemia pluripotent short-term cells

I have a problem in understanding the introduction of this paper entitled "Stability and bifurcation in a model for the dynamics of stem-like cells in leukemia under treatment". As I have no ...
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Why are stem cell therapies more preferred (theoretically) over current measures?

i understand that when stem cells are used to treat injuries using induced pluripotent stem cells (IPS), they can prevent the risk of having any tissue rejection and thus, there isn't a need for use ...
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What are null cells?

My histology textbook says the following: The pluripotential hemopoietic stemm cell (which resembles a lymphocyte) is a member of the null cell population of lymphocytes. It then goes on to add: ...
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Full name for stem cells

So during research, my professor mentioned a type of stem cell, a name that was like 5-6 words long, that can be used to treat diabetes by creating an "artificial organ". That hypothetical organ would ...
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What's the difference in roles of GATA-2 and BMI-1 in guiding Hematopietic cells?

I've discovered that hematopoietic cells become lineage-positive (Lin+) and go down the path of becoming lymphoblasts and myeloblasts, and that both BMI-1 and GATA-2 are transcription factors that ...
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Stem Cell Replication

Reading from the internet, I've come across quotes that said stem cells have the potential to replicate indefinitely. However, there are other sources that say cells that are specialised will have ...
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Is O4I2 sufficient to reprogram cells (ie induce pluripotency)? [closed]

Is exposure to the chemical O4I2 (ethyl 2-((4-chlorophenyl)amino)-thiazole-4-carboxylate) sufficient to reprogram an adult cell back to pluripotency? They sell this chemical online for pretty cheap. ...
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Can I grow unlimited stem cells from limited embryonic stem cells?

If I theoretically extract a few embryonic stem cells from the embryo and cultured in vitro with enough nutrient to grow more cells. How many maximum of stem cells can I get? Do I need to add any ...
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What is the difference between pluripotent and totipotent cells?

Both develop into specialized cells.Then how are they different?
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How does the cell cycle affect stem cell fate?

I keep reading about the stages of the cell cycle affecting stem cell fate, however I do not understand how. After all, any cell will have to pass through the whole of the cell cycle, and go through ...
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Database of time lapse stem cell differentiation

Currently I am working on a project about modelling the social behaviours of embryonic stem cells (or induced pluripotent stem cells). I need a series of time-lapse live cell images which recording ...
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In induced pluripotency experiments, what happens to the cells that do not become pluripotent?

I am new to this topic, so forgive me if my question is naïve. In an induced pluripotency experiment a few transcription factors are overexpressed in somatic cells and as a result a small portion of ...
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How far is stem cell research from being to generate a new organ?

How far are we from being able to use stem cell research to generate a sperm, a heart, a liver, and a kidney? In stem cell research, my understanding is that you must start off with some cell to ...
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What is going on in these cells?

Here are some pictures of human iPS cells in culture. After several passages, some cells look really weird, can you help me understand what is going on? What am I looking at? What are those blastocyst-...
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Special bacteria in infants

This question is similar to a previous question, but is not the same. I was told, you are born with a bacteria in your digestive track that are made by the body. Can a body in development create it'...
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Why are different mesenchymal stem cells used for articular, auricular, septal nasal and costal chondrocytes?

Why do stem cell researchers use the mesenchymal stem cells shown in the table above for these specific types of chrondrocytes? Can you only use bone marrow to make articular cartilage, or are there ...
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Myoblasts Formation

Myoblasts arise from mesenchymal stem cells (MSCs), and are precursors to myocytes. In muscles, in the basement membrane, there are also present satellite cells which can divide to generate muscle ...
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Stem cell and organ growing genitals [closed]

I've been reading a lot about stem cell research and the work on growing artificial organs. I assume, with sufficient advance in the technology, there is no theoretical reason it would not be ...
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How can one measure the effect of a stem cell's matrix on the progeny of that stem cell?

A number of recent papers that have used hydrogels to alter the ECM of mesenchymal stem cells to quicken their development to cells used specifically for cartilage or really any other type of cell. ...
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Stem cell research and female egg synthesis

In terms of years, how far is stem cell research from being able to produce a female human egg from other female body cells?
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How do stem cells produce 200 billion new blood cells every day? Does 1 stem cell division result in production of just 1 blood cell or many?

It is given on wikipedia that everyday 200 billion new blood cells are produced in the bone marrow. I want to understand how this is achieved. Does one hematopoietic stem cell's single division result ...
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Can stem cells from male convert to cells of female-only organs, and vice versa? [duplicate]

As we know, stem cells can convert to different cells of other organs, can male use their own stem cells to convert it into cells of female-only organs(and vice versa)?
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final control prior to transfecting an expression vector into a mammalian cell?

I have been asked a general question: Once I have cloned a full-length cDNA into an expression vector, what final important control must I do before I transfect this into an embryonic stem cell line? ...
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Genotype of children conceived after stem cell transplant?

If you have sickle cell disease and have a succesful stem cell or bone marrow transplant, your blood type changes to AA. But what about your future children? Do your sperm or egg cells continue to ...
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Comparing Embryonic stem cell and hepatic stem cell

So, currently, I want to compare transcriptome data for liver cell development. I found 2 data sets which start from stem cell, hepatoblast, and then adult cell. The first data set use hepatic stem ...
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Can specific B-cells be created in a lab? [closed]

Instead of creating protein sequences, could that stepped be skipped and just have B-cells created to manufacture a particular type of immunity?
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What makes diffculty to make a human bio-tooth compare to a mouse's? [closed]

Some time ago I read a news article that said a bio-engineered tooth based on a mouse's would be available around 2015. There was some research about it at King's College in the UK, and many other ...
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Could fingerprints potentially be changed using a gene gun?

Not to confuse with your "DNA fingerprint" I've read surgery is readily used to not just remove but even to change people's prints through employing very small grafts between opposing hands. About 5 ...
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Which of these methods is both effective and reliable in elongate muscle and tendon for use in humans: growth factors or stem cell technology

Which method is it the most effective, but also the most reliable for elongating muscle and tendons for clinical trial; using modern growth factor technology or using modern stem cell technology? ...
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Are stem cell lines cryogenically preserved or commercially available like HeLa cells are?

There are HeLa cells, which were taken from sick cancer patient and now is growing worldwide in different laboratories for experiments. HeLa cells can be kept because they are immortal and so they are ...
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from an ageing reproductive stem cell's DNA to baby's “brand new” somatic cells' DNA

On the one hand, somatic cells's DNA age as life goes on, mitosis after mitosis, and that is reflected into reduced telomeres. On the other hand, during life, reproductive stem cells must age too. ...